| Improved Packaging Development for Blister Packs by Using Finite Element Analysis Hans-Dieter Laux Klöckner Pentaplast GmbH & CO. KG |
Biography Starting the career at the Plastics and Films division of the former Hoechst AG, more than 20 years of experience in packaging have been collected. Worked for flexible films for food and technical applications, followed by 3 years of scientific work in environmental affairs, recycling and waste management for plastic films especially for PVC. For the last ten years working for Klöckner Pentaplast in the Business Unit Pharmaceutical Films responsible for International Marketing and Sales and member of the Innovations Team for pharmaceutical packaging applications. Company Profile The Klöckner Pentaplast Group is the world’s leading producer of films for pharmaceutical, medical device, food, electronics, and general-purpose thermoform packaging, as well as printing and specialty applications. Founded in For the pharmaceutical and medical industry Klöckner Pentaplast offers a broad range of mono and multilayer barrier films based on a diversified choice of polymers suitable for a wide range of primary and secondary packaging applications for optimum protection of sensitive drugs and devices. All films are globally available from dedicated production facilities located throughout the world.
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Abstract Solid doses and medical devices are mainly packed in blisters. More and more sophisticated drug developments, new presentation forms and high-value/high sensitive products result in continuous increase of the requirements for blister packaging. Using the latest developments in materials and technical features, pharmaceutical and medical companies can profit in higher security, faster development, reduced time-to-the market and higher line efficiencies. Finite Element Analysis is a method for scientific approach for continuous improvement of blister packs by using innovative computer modeling software. A software program for development of pharmaceutical blister and medical device packages based on finite-element analysis is intended to improve blister design and the selection of optimized packaging films. Package designers, technicians and engineers can explore the effects of tool geometry, film characteristics and process conditions before running experiments avoiding expensive production line trials and tooling costs. The program provides thickness distribution, surface area and barrier evaluation/permeability estimates of CAD simulated cavities. Using these calculations, package engineers are able to design optimal blisters considering product shapes and barrier requirements and to select the right material helping to reduce the numbers of stability tests. The software also helps to evaluate barrier improvement and optimization for existing tools and films.
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