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Atom SHARP Microneedles, the Missing Link in Microneedle Drug Delivery Jeroen Wissink U-Needle BV |
Biography Jeroen M. Wissink (born 26 November 1971 in Denekamp, The Netherlands) is managing director and co-founder of Medspray in the Netherlands. He has a technical background and developed micromachined fluidic devices for Life Sciences at former microtechnology group at 3T BV and the MESA+ Research Institute at the University of Twente, and specialized in aerosol drug delivery devices.He is a member of the MAD (‘Dutch Medical Aerosol Think-tank).
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Abstract Micro-needle technologies overcome skin barrier layers without penetrating to nerves, and are therefore potentially pain-free. By penetrating the stratum corneum (10 um) and the epidermis (100 um) medicines or vaccines are delivered into the dermis (100 - 400 um). In the field of micro-needles, University of Twente (Netherlands) has been very active over the past decade, contributing to a large knowledge base. (among others, Gardeniers / Yeshurun (nanopass) / Berenschot / De Boer 2003-2007, Tas 2005, Verbaan 2006, Luttge 2007 ). In 2008 a spin-off is initiated, uneedle, which is centred around a novel silicon (Atom Sharp) needle (tip), created with innovative etching techniques. Silicon has become accepted in the medical & pharmaceutical industry, especially in the needle area, but since silicon and manufactured silicon needles are very different from steel and conventional metal needles, this has a large impact. Some advantages and disadvantages of silicon will be highlighted. Initial data available on the newest Atom Sharp Needles will be shown, like penetration/force tests.
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