Functionalizing Micropatterned Conducting Polymers for Cell Processing Niels Bent Larsen DTU Nanotech, Technical University of Denmark Email: niels.b.larsen@nanotech.dtu.dk
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Biography Niels B. Larsen did his Ph.D. at the Department of Chemistry at University of Copenhagen where he worked on the fabrication and structural analysis of self-assembled molecular nanostructures. During this time, he spent half a year at IBM Research Laboratories in Zürich. After finishing his Ph.D. in 1996, Niels B. Larsen moved to Risø National Laboratory as a Post.Doc, then as Senior Scientist in 1999, and in 2003 he was appointed Research professor at the Danish Polymer Centre and in the Biosystems Department. In 2006, Niels B. Larsen was also appointed Adjoined Professor of the Department of Physics and Chemistry at University of Southern Denmark. Since 2008, he has been a Research professor at Dept. of Micro- and Nanotechnology, Technical University of Denmark (DTU Nanotech) Niels B. Larsen was in charge of establishing Risø’s advanced surface analysis capabilities directed at polymer materials, and was key responsible for the construction of the Risø clean room facility, CleaR, dedicated to micro- and nanoprocessing of organic materials. His main research interest is the use of advanced polymer surface engineering to establishment defined interfaces between biological systems and man-made materials.
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Abstract In vitro cell culture increasingly calls for active control of the local cell environment, e.g. to monitor cell viability or to induce a particular differentiation of the cells during culture. Conducting polymers fulfills many of the requirements for active control of living systems. The introduction of specific biological functions to the conducting polymer surface, e.g. by alkyne/azide “click-chemistry”, will make it further useful. Here, we introduce electroclicking, a new technique capable of selective chemical modification of conducting polymer electrode sets under electrochemical control. The technique can modify 20 µm wide electrode pairs separated by 20 µm with high specificity, and multiple types of alkyne-modified chemistry may be directed to neighboring electrodes.
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