Technologies for the Release of Active Molecules from Solid Surfaces and Plastic Devices Anna V. Svensson Danish Technological Institute, Center for Plastic Technology Email: ansv@teknologisk.dk
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Biography Anna V. Svensson received her M.Sc. degree in Chemical Engineering in 1997 and Ph.D. degree in Physical Chemistry in 2003 at Lund University in Sweden. The Ph.D. thesis concerned phase behavior of polymer-surfactant mixtures. She performed a research project at Aventis Pharma in Paris, France, in 2002. She worked as a post-doctoral fellow in industrial research projects at Lund University in collaborations with AstraZeneca and Procter&Gamble, before joining the Center for Plastics Technology at the Danish Technological Institute as senior consultant in 2006. Company Profile The Danish Technological Institute (DTI) is a self-owned and non-profit institution, who develops, applies and disseminates research- and technologically-based knowledge for Danish and international business sectors. DTI carries out consultancy and standardisation services and initiates R&D projects with companies and research institutions in Denmark and abroad. The Center for Plastics Technology performs commercial activities and R&D within areas of plastic processing and analysis, polymer composites, medical technology and materials for the energy sector. The turnover of DTI was 113 million EUR in 2009 and the number of employees was 904. DTI has locations in Taastrup, Aarhus, Kolding, Odense, Roskilde, Jyllinge and Hirtshals in Denmark, with subsidiaries in Sweden and Poland.
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Abstract Chemical modification of surfaces of medical devices can be of use to create bioactive and biocompatible surfaces. A surface modification typically involves pre-treatment steps followed by surface chemistry to obtain bioimmobilization, surface derivatization and/or to induce release properties to a material. Surface chemistry can be a challenge compared to ordinary bulk chemistry due to the limited amount of material and the unique reactivity conditions for the surface atoms. In the talk, some technologies will be presented which can be used to give new surface properties for metals and plastics in medical devices. The technologies include surface modifications by coatings of hydrogels and active molecules, and how to create release by depot reservoirs using encapsulation of additives in plastic or interpenetrating polymer networks.
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