Hansen Solubility Parameters used in Drug Delivery and Medical Packaging Applications Charles M. Hansen Charles M. Hansen Consulting |
Biography Charles M. Hansen was born in Louisville, Kentucky, but never the less described the fundamentals of what are now called Hansen Solubility Parameters (HSP) in a doctoral dissertation at the Technical University of Denmark in 1967. In the interim he has been employed at the PPG Industries R/D Center near Pittsburgh (1967-1976) before returning to Denmark (again) as Director of the Scandinavian Paint and Printing Ink Research Institute. He later worked at FORCE Technology solving many polymer related problems for industry. Now in a presumed state of semi-retirement, he is encouraging activities related to the HSP.
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Abstract The background for the Hansen solubility parameters (HSP) In short the forces holding a liquid together are all overcome on its evaporation. The latent heat (energy) of vaporization has quantitatively been divided into dispersion (atomic) forces, polar (molecular) forces, and (molecular) hydrogen bonding forces. The sum of the energy derived from each of these must equal that found in evaporation. The HSP of a large number of gases, liquids, solids, and polymers has been found by a number of techniques described elsewhere [1,2]. Since like prefers to be together with like, comparisons of the HSP for these indicates what will dissolve in what, what will permeate through what, and what will adsorb on what.
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